LowTE Florida DIM Product Description

3,3'-Diindolylmethane, often abbreviated as DIM, is one of the most powerful compounds found in nature, most prominently sourced in the diet from the cruciferous class of vegetables, which includes broccoli, bok choy, Brussels sprouts, cauliflower, and spinach,

In our patented LowTE Florida supplement, LowTE Florida DIM, we’ve extracted the compound, concentrated it, and packed 150 mg doses into every capsule.

Here’s what DIM is, why it’s an excellent adjunct therapy to supplement bioidentical hormone replacement therapy (BHRT) for both women and women, and how we maximize its benefits in our leading anti-aging LowTE Florida office alongside hormone therapy.

What is DIM and why is it an essential anti-aging supplement?

Derived from indole-3-carbinol (I3C), DIM is one of the main bioactive compounds that lend cruciferous veggies their numerous health-promoting properties.

Among its many activities in vitro, DIM:

• Regulates and balances hormones in both men and women
• Alleviates PCOS, perimenopause, and menopause symptoms in women
• Elevates testosterone levels in men
• Prevents cancer cell growth (metastasis)
• Stimulates fat breakdown (lipolysis), inhibits fall cell development, and promotes weight loss
• Treats and prevents acne

Research shows DIM may help prevent diabetes, heart disease, and cancer

Due to its unique activity in vivo, clinical research has linked DIM to the possible prevention of heart disease, diabetes, and multiple forms of cancer.

From Advances in Experimental Medicine and Biology (emphasis added):

“Indole-3-carbinol (I3C), a common phytochemical in cruciferous vegetables, and its condensation product, 3,3'-diindolylmethane (DIM) exert several biological activities on cellular and molecular levels, which contribute to their well-recognized chemoprevention potential. Initially, these compounds were classified as blocking agents that increase drug-metabolizing enzyme activity. Now it is widely accepted that I3C and DIM affect multiple signaling pathways and target molecules controlling cell division, apoptosis, or angiogenesis deregulated in cancer cells. Although most of the current data support the role of I3C and DIM in prevention of hormone-dependent cancers, it seems that their application in prevention of the other cancer as well as cardiovascular disease, obesity, and diabetes reduction is also possible. This chapter summarizes the current experimental data on the I3C and DIM activity and the results of clinical studies indicating their role in prevention of chronic diseases.”

Prostate cancer is the second most common form of cancer occurring in men worldwide and is largely tied to hormone levels. Correcting hormonal imbalances, therefore, is key to preventing and treating prostate cancer.

In both breast cancer and prostate cancer, “DIM has been shown to induce a dose dependent apoptosis by inhibiting AKT kinase and IKK-mediated phosphorylation, thus leading to decreased cell growth and proliferation” according to research published in Thyroid.

In fact, the degree to which DIM reduces prostate cancer risk in men is stunning: “In mice injected TRAMP-C2 mouse prostate cancer cells, DIM significantly reduced tumor development to 50% compared with controls,” per The Journal of Biomedical Research. “Tumors in treated mice were significantly smaller than control animals.”

For these reasons and more, which we’ll explore below, supplementing with DIM is one of the most effective yet simple strategies to lengthen both the lifespan and health span of older adults, often paired with bioidentical hormone replacement therapy.

DIM promotes optimal hormone health, testosterone levels in men

Research has demonstrated that up to a quarter of men over 40 experience testosterone deficiency (TD), also known as hypogonadism, which results in a slew of symptoms including erectile dysfunction (ED), lost muscle mass, increased body fat, and chronic fatigue.

The main way that DIM improves testosterone levels in men is through the natural inhibition of the enzyme called aromatase that is responsible for converting testosterone (the male sex hormone) to estrogen (the main female sex hormone).

Additionally, evidence suggests that DIM might improve the critical ratio of free testosterone to bound testosterone — the former of which, free testosterone, being critical to men’s hormone health as it is the “unbound” and thus bioactive form of the male sex hormone.

DIM promotes optimal hormone health in women

In women, DIM optimizes testosterone levels as it does for men, regulates estrogen levels, and improves the ratio of the “good” form of estrogen to the “bad” form of estrogen, each of which with massive positive implications for women’s anti-aging wellness as well as the treatment of numerous hormone-related conditions.

Not all estrogen is created equal; DIM is particularly useful for stimulating the production of a more beneficial form of estrogen, 2-hydroxyestrone (2-OHE1), while limiting the production of 16-alpha-hydroxyestrone (16α-OH-E1), the form of estrogen responsible for many hormone-related health conditions in women.

DIM decreases cervical and breast cancer risk

A vast trove of clinical studies on both human and animal subjects demonstrates that DIM dramatically reduces both cervical cancer (cervical dysplasia) and breast cancer risk in women with minimal side effects.

“Animal studies with mice and rats using either cabbage, I3C, or DIM resulted in a decrease in both spontaneous and chemically induced mammary tumors, and no side effects were noted,” notes the Nutrition and Cancer. “A decrease in cervical dysplasia was noted in approximately 50% of the women given oral I3C, and no significant side effects were observed.”

“DIM modulates estrogen metabolism, thus generating metabolites with antiestrogenic activity. An increased 2/16-OHE1 ratio favors a decrease in the long-term risk for developing cancer and thus has potential to be associated with the chemo preventive activity of DIM,” according to additional research published in Thyroid.

DIM successfully treats PCOS

As “a complex condition characterized by elevated androgen levels, menstrual irregularities, and/or small cysts on one or both ovaries” and associated with abnormally low 2-OHE1 — which, again, DIM help correct — polycystic ovary syndrome (PCOS) is the single most common hormone-related disorder in women, affecting upwards of 25% of women at some point in their lives.

Because the condition is characterized, somewhat paradoxically, both by estrogen dominance and abnormally elevated testosterone levels, DIM supplementation is an excellent frontline therapy to treat PCOS.

“Diindolylmethane (DIM) 100mg daily was added both for its beneficial effects on estrogen metabolism and its antiandrogen effects,” researchers reported in one case study of the benefits of DIM as a potential therapeutic for PCOS published in Integrative Medicine. “Cycles remained regular, and symptoms were well controlled with DIM and acupuncture maintenance therapy.”

DIM for perimenopause, menopause, and post menopause

In women experiencing any of the three phases of menopause — perimenopause, menopause, and post menopause — estrogen imbalance is the main culprit due to fluctuating hormone levels.

Through the mechanism described above of improving the 2/16-OHE1 ratio, DIM can help alleviate numerous symptoms associated with menopause, including:

• Weight gain
• Irregular periods
• Hot flashes
• Sleep disturbances
• Irritability
• Impaired mental health
• Vaginal dryness
• Loss of sex drive (libido)

LowTE Florida DIM dosing schedule for men and women

Each LowTE Florida DIM capsule contains 150 milligrams (mg) of 3,3'-Diindolylmethane.

The dosing regimen depends on the sex of the patient:

• Men take two capsules per day, one in the morning and one in the evening
• Women take one capsule per day, ideally in the morning

In addition to offering industry-leading, high-potency DIM free of harmful additives, LowTE Florida DIM is:

• Dairy free
• Gluten free
• Soy free

100% Money-back guarantee

Each and every one of our proprietary LowTE Florida supplements comes with an ironclad 100% money-back guarantee. If, for whatever reason, you are not completely satisfied with the product, please feel free to contact us and we’ll quickly get your money refunded — no hassles, no questions asked.

Questions? Contact us

We’re here to help our patients with any concerns or questions you might have regarding the numerous high-quality supplements featured at our wholesale online store (LowTEshop.com).